OpenMedTech Lab Empowering lives through innovation

Research

Our research focuses on neural engineering, neurorehabilitation, neuromodulation, neuroprosthetics and brain–computer interfaces for restoring function following neurological injury and disease. By integrating bioelectronic medicine, rehabilitation robotics, wearable medical devices and assistive technologies, we develop innovative solutions that enhance mobility, independence and quality-of-life for people living with disability. Our key research includes:

Highlighted

OpenXstim: an open-source programmable electrical stimulator for transcutaneous spinal cord stimulation therapy
OpenXstim: an open-source programmable electrical stimulator for transcutaneous spinal cord stimulation therapy
Monzurul Alam, Vaheh Nazari, Md Akhlasur Rahman, Vijayapriya Arumugam, Naveena Narayanan, Farjana Taoheed, Md Shofiqul Islam, Padmanabhan Thirunavukkarasu, Mohammad Sohrab Hossain, Alistair McEwan
Journal of Neural Engineering  ·  27 Nov 2025  ·  doi:10.1088/1741-2552/ae20c2
This programmable, open-source neurostimulator offers tangible hope for expanding access to non-invasive neuromodulation research and treatments for people with paralysis worldwide.
Restoration of Over-Ground Walking via Non-Invasive Neuromodulation Therapy: A Single-Case Study
Restoration of Over-Ground Walking via Non-Invasive Neuromodulation Therapy: A Single-Case Study
Monzurul Alam, Yan To Ling, Md Akhlasur Rahman, Arnold Yu Lok Wong, Hui Zhong, V. Reggie Edgerton, Yong-Ping Zheng
Journal of Clinical Medicine  ·  28 Nov 2023  ·  doi:10.3390/jcm12237362
This breakthrough non-invasive neuromodulation therapy challenges the long-standing belief that chronic paralysis is irreversible, demonstrating meaningful sensorimotor recovery and the restoration of over-ground walking after more than two decades of spinal cord injury.

All

2025

OpenXstim: an open-source programmable electrical stimulator for transcutaneous spinal cord stimulation therapy
OpenXstim: an open-source programmable electrical stimulator for transcutaneous spinal cord stimulation therapy
Monzurul Alam, Vaheh Nazari, Md Akhlasur Rahman, Vijayapriya Arumugam, Naveena Narayanan, Farjana Taoheed, Md Shofiqul Islam, Padmanabhan Thirunavukkarasu, Mohammad Sohrab Hossain, Alistair McEwan
Journal of Neural Engineering  ·  27 Nov 2025  ·  doi:10.1088/1741-2552/ae20c2
This programmable, open-source neurostimulator offers tangible hope for expanding access to non-invasive neuromodulation research and treatments for people with paralysis worldwide.
Feasibility, usability, and acceptability of a novel open-source low-cost manual standing wheelchair in low economic settings
Feasibility, usability, and acceptability of a novel open-source low-cost manual standing wheelchair in low economic settings
Farjana Taoheed, Shovan Parvez, Md Akhlasur Rahman, Muzaffor Hossain, Mohammad Anwar Hossain, Md. Obaidul Haque, Valerie Ann Taylor, Mohammad Sohrab Hossain, Monzurul Alam
Disability and Rehabilitation: Assistive Technology  ·  21 Nov 2025  ·  doi:10.1080/17483107.2025.2591868
This affordable, open-source standing wheelchair offers tangible hope for reducing global disparities in access to assistive technologies by enabling independent standing and improving participation, health, and well-being for people with paralysis.
Mobile Trans-Spinal Electrical Stimulation Therapy for Spinal Cord Injury
Mobile Trans-Spinal Electrical Stimulation Therapy for Spinal Cord Injury
Md Akhlasur Rahman, Farjana Taoheed, Peter Sturgess, Alistair McEwan, Monzurul Alam
Automation in Tele-Neurorehabilitation  ·  17 Sep 2025  ·  doi:10.1201/9781003419235-8

2024

Effects of non-invasive cervical spinal cord neuromodulation by trans-spinal electrical stimulation on cortico-muscular descending patterns in upper extremity of chronic stroke
Effects of non-invasive cervical spinal cord neuromodulation by trans-spinal electrical stimulation on cortico-muscular descending patterns in upper extremity of chronic stroke
Jianing Zhang, Maner Wang, Monzurul Alam, Yong-Ping Zheng, Fuqiang Ye, Xiaoling Hu
Frontiers in Bioengineering and Biotechnology  ·  21 Mar 2024  ·  doi:10.3389/fbioe.2024.1372158

2023

Restoration of Over-Ground Walking via Non-Invasive Neuromodulation Therapy: A Single-Case Study
Restoration of Over-Ground Walking via Non-Invasive Neuromodulation Therapy: A Single-Case Study
Monzurul Alam, Yan To Ling, Md Akhlasur Rahman, Arnold Yu Lok Wong, Hui Zhong, V. Reggie Edgerton, Yong-Ping Zheng
Journal of Clinical Medicine  ·  28 Nov 2023  ·  doi:10.3390/jcm12237362
This breakthrough non-invasive neuromodulation therapy challenges the long-standing belief that chronic paralysis is irreversible, demonstrating meaningful sensorimotor recovery and the restoration of over-ground walking after more than two decades of spinal cord injury.

2022

Combined Transcutaneous Electrical Spinal Cord Stimulation and Task-Specific Rehabilitation Improves Trunk and Sitting Functions in People with Chronic Tetraplegia
Combined Transcutaneous Electrical Spinal Cord Stimulation and Task-Specific Rehabilitation Improves Trunk and Sitting Functions in People with Chronic Tetraplegia
Niraj Singh Tharu, Monzurul Alam, Yan To Ling, Arnold YL Wong, Yong-Ping Zheng
Biomedicines  ·  23 Dec 2022  ·  doi:10.3390/biomedicines11010034
Caregivers Knowledge, Attitude, and Practice towards Pressure Injuries in Spinal Cord Injury at Rehabilitation Center in Bangladesh
Caregivers’ Knowledge, Attitude, and Practice towards Pressure Injuries in Spinal Cord Injury at Rehabilitation Center in Bangladesh
Niraj Singh Tharu, Monzurul Alam, Shristi Bajracharya, Gautam Prasad Chaudhary, Jitendra Pandey, Mohammad A. Kabir
Advances in Orthopedics  ·  14 Jun 2022  ·  doi:10.1155/2022/8642900
Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review
Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review
Md. Akhlasur Rahman, Niraj Singh Tharu, Sylvia M. Gustin, Yong-Ping Zheng, Monzurul Alam
Journal of Clinical Medicine  ·  11 Mar 2022  ·  doi:10.3390/jcm11061550
Effect of Cervical Transcutaneous Spinal Cord Stimulation on Sensorimotor Cortical Activity during Upper-Limb Movements in Healthy Individuals
Effect of Cervical Transcutaneous Spinal Cord Stimulation on Sensorimotor Cortical Activity during Upper-Limb Movements in Healthy Individuals
Ciarán McGeady, Monzurul Alam, Yong-Ping Zheng, Aleksandra Vučković
Journal of Clinical Medicine  ·  17 Feb 2022  ·  doi:10.3390/jcm11041043
Treating spinal cord injury with implanted spinal cord stimulators
Treating spinal cord injury with implanted spinal cord stimulators
Hengze You, Yong-Ping Zheng, Monzurul Alam
Diagnosis and Treatment of Spinal Cord Injury  ·  01 Jan 2022  ·  doi:10.1016/B978-0-12-822498-4.00019-1

2021

A Compact and Lightweight Rehabilitative Exoskeleton to Restore Grasping Functions for People with Hand Paralysis
A Compact and Lightweight Rehabilitative Exoskeleton to Restore Grasping Functions for People with Hand Paralysis
Vaheh Nazari, Majid Pouladian, Yong-Ping Zheng, Monzurul Alam
Sensors  ·  18 Oct 2021  ·  doi:10.3390/s21206900
EEG Monitoring Is Feasible and Reliable during Simultaneous Transcutaneous Electrical Spinal Cord Stimulation
EEG Monitoring Is Feasible and Reliable during Simultaneous Transcutaneous Electrical Spinal Cord Stimulation
Ciarán McGeady, Aleksandra Vučković, Yong-Ping Zheng, Monzurul Alam
Sensors  ·  02 Oct 2021  ·  doi:10.3390/s21196593
Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in people with chronic pain
Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in people with chronic pain
David Kang, Negin Hesam‐Shariati, James H. McAuley, Monzurul Alam, Zina Trost, Caroline D. Rae, Sylvia M. Gustin
European Journal of Pain  ·  26 Jul 2021  ·  doi:10.1002/ejp.1838
Low Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing
Low‐Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing
Poornima Palanisamy, Monzurul Alam, Shuai Li, Simon K. H. Chow, Yong‐Ping Zheng
Journal of Ultrasound in Medicine  ·  05 May 2021  ·  doi:10.1002/jum.15738
Serotonergic Facilitation of Forelimb Functional Recovery in Rats with Cervical Spinal Cord Injury
Serotonergic Facilitation of Forelimb Functional Recovery in Rats with Cervical Spinal Cord Injury
Benita Jin, Monzurul Alam, Alexa Tierno, Hui Zhong, Roland R. Roy, Yury Gerasimenko, Daniel C. Lu, V. Reggie Edgerton
Neurotherapeutics  ·  01 Apr 2021  ·  doi:10.1007/s13311-020-00974-8
Can Prosthetic Hands Mimic a Healthy Human Hand
Can Prosthetic Hands Mimic a Healthy Human Hand?
Ka Ho Ng, Vaheh Nazari, Monzurul Alam
Prosthesis  ·  28 Jan 2021  ·  doi:10.3390/prosthesis3010003
Buspirone Dose-Response on Facilitating Forelimb Functional Recovery in Cervical Spinal Cord Injured Rats
Buspirone Dose-Response on Facilitating Forelimb Functional Recovery in Cervical Spinal Cord Injured Rats
Rakib Uddin Ahmed, V. Reggie Edgerton, Shuai Li, Yong-Ping Zheng, Monzurul Alam
Dose-Response  ·  01 Jan 2021  ·  doi:10.1177/1559325821998136

2020

Restoration of arm and hand functions via noninvasive cervical cord neuromodulation after traumatic brain injury: a case study
Restoration of arm and hand functions via noninvasive cervical cord neuromodulation after traumatic brain injury: a case study
Qiuyang Qian, Yan To Ling, Hui Zhong, Yong-Ping Zheng, Monzurul Alam
Brain Injury  ·  02 Dec 2020  ·  doi:10.1080/02699052.2020.1850864
Ultrasound-driven piezoelectric current activates spinal cord neurocircuits and restores locomotion in rats with spinal cord injury
Ultrasound-driven piezoelectric current activates spinal cord neurocircuits and restores locomotion in rats with spinal cord injury
Shuai Li, Monzurul Alam, Rakib Uddin Ahmed, Hui Zhong, Xiao-Yun Wang, Serena Ng, Yong-Ping Zheng
Bioelectronic Medicine  ·  01 Jun 2020  ·  doi:10.1186/s42234-020-00048-2
Reversing 21 years of chronic paralysis via non invasive spinal cord neuromodulation: a case study
Reversing 21 years of chronic paralysis via non‐invasive spinal cord neuromodulation: a case study
Monzurul Alam, Yan To Ling, Arnold Y. L. Wong, Hui Zhong, Victor Reggie Edgerton, Yong‐Ping Zheng
Annals of Clinical and Translational Neurology  ·  01 May 2020  ·  doi:10.1002/acn3.51051

2019

Spinal Cord Injury: Lessons about Neuroplasticity from Paired Associative Stimulation
Spinal Cord Injury: Lessons about Neuroplasticity from Paired Associative Stimulation
Yan To Ling, Monzurul Alam, Yong-Ping Zheng
The Neuroscientist  ·  31 Dec 2019  ·  doi:10.1177/1073858419895461
Development of a battery-free ultrasonically powered functional electrical stimulator for movement restoration after paralyzing spinal cord injury
Development of a battery-free ultrasonically powered functional electrical stimulator for movement restoration after paralyzing spinal cord injury
Monzurul Alam, Shuai Li, Rakib Uddin Ahmed, Yat Man Yam, Suman Thakur, Xiao-Yun Wang, Dan Tang, Serena Ng, Yong-Ping Zheng
Journal of NeuroEngineering and Rehabilitation  ·  08 Mar 2019  ·  doi:10.1186/s12984-019-0501-4
Experimental spinal cord injury and behavioral tests in laboratory rats
Experimental spinal cord injury and behavioral tests in laboratory rats
Rakib Uddin Ahmed, Monzurul Alam, Yong-Ping Zheng
Heliyon  ·  01 Mar 2019  ·  doi:10.1016/j.heliyon.2019.e01324

2018

Diagnosis and treatment of diastematomyelia in children: a perspective cohort study
Diagnosis and treatment of diastematomyelia in children: a perspective cohort study
Sergey V. Vissarionov, Nikolay A. Krutelev, Victor P. Snischuk, Monzurul Alam, Artem P. Kravchenko, Yong-Ping Zheng, Nikita O. Khusainov
Spinal Cord Series and Cases  ·  19 Dec 2018  ·  doi:10.1038/s41394-018-0141-0
Closed-loop stimulation of the pelvic nerve for optimal micturition
Closed-loop stimulation of the pelvic nerve for optimal micturition
Wendy Yen Xian Peh, Marlena N Raczkowska, Yuni Teh, Monzurul Alam, Nitish V Thakor, Shih-Cheng Yen
Journal of Neural Engineering  ·  25 Sep 2018  ·  doi:10.1088/1741-2552/aadee9
Measurement of neurovascular coupling in human motor cortex using simultaneous transcranial Doppler and electroencephalography
Measurement of neurovascular coupling in human motor cortex using simultaneous transcranial Doppler and electroencephalography
Monzurul Alam, Ghazanfar Ahmed, Yan To Ling, Yong-Ping Zheng
Physiological Measurement  ·  01 Jun 2018  ·  doi:10.1088/1361-6579/aac812

2017

Electrical neuromodulation of the cervical spinal cord facilitates forelimb skilled function recovery in spinal cord injured rats
Electrical neuromodulation of the cervical spinal cord facilitates forelimb skilled function recovery in spinal cord injured rats
Monzurul Alam, Guillermo Garcia-Alias, Benita Jin, Jonathan Keyes, Hui Zhong, Roland R. Roy, Yury Gerasimenko, Daniel C. Lu, V. Reggie Edgerton
Experimental Neurology  ·  01 May 2017  ·  doi:10.1016/j.expneurol.2017.02.006
Motor neuroprosthesis for injured spinal cord: who is an ideal candidate
Motor neuroprosthesis for injured spinal cord: who is an ideal candidate?
Monzurul Alam, Yong-ping Zheng
Neural Regeneration Research  ·  01 Jan 2017  ·  doi:10.4103/1673-5374.219041

2016

Unique Spatiotemporal Neuromodulation of the Lumbosacral Circuitry Shapes Locomotor Success after Spinal Cord Injury
Unique Spatiotemporal Neuromodulation of the Lumbosacral Circuitry Shapes Locomotor Success after Spinal Cord Injury
Prithvi K. Shah, Shakthi Sureddi, Monzurul Alam, Hui Zhong, Roland R. Roy, V. Reggie Edgerton, Yury Gerasimenko
Journal of Neurotrauma  ·  01 Sep 2016  ·  doi:10.1089/neu.2015.4256
Brain-machine interface facilitated neurorehabilitation via spinal stimulation after spinal cord injury: Recent progress and future perspectives
Brain-machine interface facilitated neurorehabilitation via spinal stimulation after spinal cord injury: Recent progress and future perspectives
Monzurul Alam, Willyam Rodrigues, Bau Ngoc Pham, Nitish V. Thakor
Brain Research  ·  01 Sep 2016  ·  doi:10.1016/j.brainres.2016.05.039

2015

An economic method to build a puffing instrument for drug application in vitro
An economic method to build a puffing instrument for drug application in vitro
Yiping Guo, Chunhua Liu, Lingli Hu, Xiaoyun Wang, Monzurul Alam, Haitao Wang
Journal of Neuroscience Methods  ·  01 Dec 2015  ·  doi:10.1016/j.jneumeth.2015.08.032
Evaluation of optimal electrode configurations for epidural spinal cord stimulation in cervical spinal cord injured rats
Evaluation of optimal electrode configurations for epidural spinal cord stimulation in cervical spinal cord injured rats
Monzurul Alam, Guillermo Garcia-Alias, Prithvi K. Shah, Yury Gerasimenko, Hui Zhong, Roland R. Roy, V. Reggie Edgerton
Journal of Neuroscience Methods  ·  01 May 2015  ·  doi:10.1016/j.jneumeth.2015.03.012

2014

A Brain-Machine-Muscle Interface for Restoring Hindlimb Locomotion after Complete Spinal Transection in Rats
A Brain-Machine-Muscle Interface for Restoring Hindlimb Locomotion after Complete Spinal Transection in Rats
Monzurul Alam, Xi Chen, Zicong Zhang, Yan Li, Jufang He
PLoS ONE  ·  01 Aug 2014  ·  doi:10.1371/journal.pone.0103764
Electronic bypass of spinal lesions: activation of lower motor neurons directly driven by cortical neural signals
Electronic bypass of spinal lesions: activation of lower motor neurons directly driven by cortical neural signals
Yan Li, Monzurul Alam, Shanshan Guo, KH Ting, Jufang He
Journal of NeuroEngineering and Rehabilitation  ·  03 Jul 2014  ·  10.1186/1743-0003-11-107
Electronic bypass of spinal lesions: activation of lower motor neurons directly driven by cortical neural signals
Electronic bypass of spinal lesions: activation of lower motor neurons directly driven by cortical neural signals
Yan Li, Monzurul Alam, Shanshan Guo, KH Ting, Jufang He
Journal of NeuroEngineering and Rehabilitation  ·  03 Jul 2014  ·  doi:10.1186/1743-0003-11-107
Lower-Limb Neuroprostheses
Lower-Limb Neuroprostheses
Monzurul Alam, Jufang He
Advances in Bioinformatics and Biomedical Engineering  ·  08 Mar 2014  ·  doi:10.4018/978-1-4666-6094-6.ch009

2013

A low-cost multichannel wireless neural stimulation system for freely roaming animals
A low-cost multichannel wireless neural stimulation system for freely roaming animals
Monzurul Alam, Xi Chen, Eduardo Fernandez
Journal of Neural Engineering  ·  25 Oct 2013  ·  doi:10.1088/1741-2560/10/6/066010
Cortically Controlled Electrical Stimulation for Locomotion of the Spinal Cord Injured
Cortically Controlled Electrical Stimulation for Locomotion of the Spinal Cord Injured
Monzurul Alam, Jufang He
Biosystems & Biorobotics  ·  01 Jan 2013  ·  doi:10.1007/978-3-642-34546-3_6